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KMID : 0380020110260020093
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Korean Journal of Biotechnology and Bioengineering
2011 Volume.26 No. 2 p.93 ~ p.99
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Flavonoid Glycosylation Using Microbial-produced Unusual Sugar
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Oh Tae-Jin
Sohng Jae-Kyung
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Abstract
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1)Glycosylation is a key mechanism in determining diversity of natural products, and influencing their bioactivities. This approach requires a core set of glycosyltransferase that synthesizes the diverse sugar structures observed in nature. Recently, the researchers have begun to alter the sugar moiety and glycosylation patterns of natural products both in vivo E. coli system and in vitro for their glycodiversification. This review highlights new glycosylation tools using microbialproduced deoxysugar and a flexible glycosyltransferase on natural plant-flavonoids to generate novel glycoforms with useful biological activity.
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KEYWORD
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Biosynthesis, Carbohydrate, Deoxysugar, Flavonoid, Glycosylation, Glycosyltransferase
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